Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
For MTHFD1 rs2236225 polymorphism, mothers having GA genotype and A allele exhibited an increased risk of NTDs in the offspring (OR = 2.600, 95%CI: 1.227-5.529; OR = 1.847, 95%CI: 1.047-3.259).
|
30867013 |
2019 |
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Inhibition of either BRD4 or MTHFD1 results in similar changes in nuclear metabolite composition and gene expression; pharmacological inhibitors of the two pathways synergize to impair cancer cell viability in vitro and in vivo.
|
31133746 |
2019 |
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Mitochondrial MTHFD isozymes display distinct expression, regulation, and association with cancer.
|
31377316 |
2019 |
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Inhibition of either BRD4 or MTHFD1 results in similar changes in nuclear metabolite composition and gene expression; pharmacological inhibitors of the two pathways synergize to impair cancer cell viability in vitro and in vivo.
|
31133746 |
2019 |
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Mitochondrial MTHFD isozymes display distinct expression, regulation, and association with cancer.
|
31377316 |
2019 |
Hypertensive disease
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
MTHFD1 promoter hypermethylation increases the risk of hypertension.
|
30183434 |
2019 |
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
The recently identified MTHFD1 defect additionally presents with severe immune deficiency.
|
30761552 |
2019 |
Male infertility
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The chi-square test was used to determine the association between MTHFD1 G1958A polymorphism and male infertility, using SPSS software.P?0.05 was considered significant.
|
30882176 |
2019 |
Essential Hypertension
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The area under the curve (AUC) of MTHFD1 promoter methylation was 0.739 in total patients with essential hypertension.
|
30183434 |
2019 |
Acute leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA expression levels of RFC1, MS, MTRR, MTHFR and ABCB1 were decreased (P<0.05), while those of GGH, FPGS, TS and MTHFD1 (P<0.05) were overexpressed in patients with AL.
|
31452789 |
2019 |
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusion:</b> High MTHFD1 expression in HCC indicated poorer prognosis.
|
30997850 |
2019 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
For rs2236225 within MTHFD1, children with allele A or genotype AA had a high NTDs risk (OR=1.500, 95%CI=1.061~2.120; OR=2.862, 95%CI=1.022~8.015, respectively).
|
29392422 |
2018 |
Longevity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Sex Differences in Genetic Associations With Longevity.
|
30294719 |
2018 |
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The expression level of MTHFD1 was related to tumor size, TNM stage, histologic grade, and metastasis, but not linked to gender and age.
|
30343310 |
2018 |
Congenital Abnormality
|
0.030 |
GeneticVariation
|
group |
BEFREE |
A polymorphism in methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), R653Q (MTHFD1 c.1958 G > A), has also been associated with increased birth defect risk, likely through reduced purine synthesis.
|
29659962 |
2018 |
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The role of MTHFD1 in NSCLC was examined in our study.
|
30343310 |
2018 |
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
MATERIAL AND METHODS The correlation between the expression of MTHFD1 and the clinicopathological features of patients diagnosed with lung cancer was investigated using the chi-square test.
|
30343310 |
2018 |
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
MATERIAL AND METHODS The correlation between the expression of MTHFD1 and the clinicopathological features of patients diagnosed with lung cancer was investigated using the chi-square test.
|
30343310 |
2018 |
Deficiency of citrate(si)-synthase
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We aimed to determine if the interaction of MTHFD1 synthetase deficiency and low folate intake increases developmental abnormalities in a mouse model for MTHFD1 R653Q.
|
29659962 |
2018 |
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
MATERIAL AND METHODS The correlation between the expression of MTHFD1 and the clinicopathological features of patients diagnosed with lung cancer was investigated using the chi-square test.
|
30343310 |
2018 |
Esophageal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
High expression of MTHFD1 was also detected in two esophageal cancer cell lines (TE-1 and EC109).
|
29171320 |
2018 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The expression level of MTHFD1 was related to tumor size, TNM stage, histologic grade, and metastasis, but not linked to gender and age.
|
30343310 |
2018 |
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
When cells were transfected with MTHFD1-siRNA, the levels of surviving and B-cell lymphoma-2 (Bcl-2) were attenuated, while p53 and Bcl-2 associated X protein (Bax) levels were enhanced.
|
30343310 |
2018 |
Esophageal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of MTHFD1 was also detected in two esophageal cancer cell lines (TE-1 and EC109).
|
29171320 |
2018 |
Exfoliation Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests no significant genetic association of MTHFR (rs1801131, rs1801133) and MTHFD1 (rs8006686) polymorphisms in South Indian PEX patients.
|
28299500 |
2018 |